Joestar
24 characters, 23 with recorded family ties
- Joseph Joestar and Suzi Q are the parents of Holy Kujo, Josuke Higashikata and Shizuka Joestar.
- Barbara Ann Joestar is the parent of Dragona Joestar and Jodio Joestar.
- George Joestar II (Steel Ball Run) is the parent of Johnny Joestar and Nicholas Joestar.
Notable members: Joseph Joestar, Jonathan Joestar, Barbara Ann Joestar, George Joestar I, George Joestar II, George Joestar II (Steel Ball Run).
Higashikata
13 characters, 12 with recorded family ties
- Norisuke Higashikata IV and Kaato Higashikata are the parents of Daiya Higashikata, Hato Higashikata, Jobin Higashikata and Joshu Higashikata.
- Jobin Higashikata and Mitsuba Higashikata are the parents of Tsurugi Higashikata.
- Norisuke Higashikata I is the parent of Rina Higashikata.
Notable members: Norisuke Higashikata IV, Jobin Higashikata, Daiya Higashikata, Hato Higashikata, Joshu Higashikata, Kaato Higashikata.
Brando
9 characters, 8 with recorded family ties
- Dio Brando is the parent of Donatello Versus, Giorno Giovanna, Rikiel and Ungalo.
- Dario Brando is the parent of Dio Brando.
Notable members: Dio Brando, Dario Brando, Diego Brando (Scary Monsters), Donatello Versus, Giorno Giovanna, Rikiel.
Hirose
5 characters, 5 with recorded family ties
- Suzuyo Hirose is the parent of Yasuho Hirose.
Notable members: Ayana Hirose, Koichi Hirose, Suzuyo Hirose, Yasuho Hirose.
Kujo
5 characters, 5 with recorded family ties
- Jotaro Kujo is the parent of Jolyne Cujoh.
- Kiyomi Kujo is the parent of Josefumi Kujo.
- Sadao Kujo is the parent of Jotaro Kujo.
Notable members: Jotaro Kujo, Jolyne Cujoh, Josefumi Kujo, Kiyomi Kujo, Sadao Kujo.
Zeppeli
5 characters, 5 with recorded family ties
- Gregorio Zeppeli is the parent of Gyro Zeppeli.
- Mario Zeppeli is the parent of Caesar Anthonio Zeppeli.
- Will Anthonio Zeppeli is the parent of Mario Zeppeli.
Notable members: Mario Zeppeli, Caesar Anthonio Zeppeli, Gregorio Zeppeli, Gyro Zeppeli, Will Anthonio Zeppeli.
Motorize
5 characters, 4 with recorded family ties
- Ben Motorize is the parent of Darlington Motorize, Kenton Motorize and Steven Motorize.
Notable members: Ben Motorize, Darlington Motorize, Kenton Motorize, Steven Motorize.
Valentine
5 characters, 4 with recorded family ties
- Funnier Valentine is the parent of The Funniest Valentine.
Notable members: Funnier Valentine, Funny Valentine, Scarlet Valentine, The Funniest Valentine.
Pucci
4 characters, 4 with recorded family ties
- Mrs. Bluemarine is the parent of Enrico Pucci, Perla Pucci and Weather Report.
Notable members: Mrs. Bluemarine, Enrico Pucci, Perla Pucci, Weather Report.